And so the story about "digging for earthworm, and finding a snake" :-) It all started with me being sick for much of last month. I was finally diagnosed after multiple blood tests, chest x-rays and umpteen other tests to be suffering from mononucleosis. It is a common viral infection here, caused by the Epstein-Barr Virus. Aparently it weakens the body quite a bit, and I was advised no-strain for a few months. Interestingly, I also learnt from the doctor (after spending almost all the afternoons of last week at the medical centre) why no anti-virus vaccines can't be made. Because, unlike bacteria, the virus mutates very fast in the course of weeks or months or years. So, it is extremely difficult and not cost-effective to create a anti-viral only for it to be become ineffective in sometime.
Anyways, now for the snake part. I had my blood profile done and I seemed to have a less than normal MCV ad MCH. Those are mean volume and size of haemoglobin cells. In trying to figure out the cause for that, they did a haemoglobinopathy profile. And today the doctor called me up to say that I had Haemoglobin E trait heterozygous. It is a genetic trait, caused by substitution of lysine for glutamic acidat position 26 of the chromosome. This interferes with mRNA processing. But, I was heterozygoes, and it is a recessive gene, so I was a carrier, not affected by it. So, instead of 94-98 % haemoglobin A, I had 75% A, and 25% of this mutated haemoglobin E. This aparently is very prevalent in south east asia, mainly Cambodia and Thailand, but also in south east asia, bangladesh and north-east india. This is also the second most common haeomoglobin disorder after sickle cell anaemia. Learnt a lot about haemoglobin, including the different types - A, S (sickle cell), C, A1, F, etc. So, my condition in benign. And there has been some research done on the reason behind the extent of this mutation in parts of the world. Aparently, it is not proved, but this might decrease the chance of malaria happening, which is very common in these parts of the world. Sickle cell provably prevents malaria germ from infecting. So, interestingly Darwin's natural selection chose this mutant variety because it is fitter to survive in these climes. Amazing. And it piqued again my latent and intensive interest in genetics.
Sources:
1.
Haemoglobin E - orpanet2.
Hemoglobinopathies - Harvard3.
Thalassemia - Virginia4.
Final diagnosis - UPitt